Zembrace® SymTouch®

An auto-injector with the thinnest needle of its kind, delivering sumatriptan just under the skin

Image for ZEMBRACE SYMTOUCH (Sumatriptan Injection) 3 mg

Not actual size.

Results

Provides fast and effective pain relief for migraine attacks

In a clinical trial, patients taking ZEMBRACE SYMTOUCH were:

2-hour

Free from migraine pain 2 hours after dosing*

Almost half of patients were pain‑free 2 hours after dosing (46% vs 27% with placebo).

In a clinical study using a different sumatriptan injector with equivalent doses, patients experienced:

2-hour

Migraine relief 2 hours after dosing†

60% of patients reported migraine relief 2 hours after dosing (vs 21% with placebo).
10-minute

Fast relief in as little as 10 minutes†

17% of patients reported migraine relief at 10 minutes (vs 5% with placebo).

*Pain freedom meant patients said their migraine pain went from moderate or severe to no pain at all 2 hours after taking their first dose.

†Relief meant patients’ pain improved from moderate or severe to mild or no pain after taking their medication—without needing any additional (rescue) medicine.

Side Effects

The most common side effects of ZEMBRACE SYMTOUCH (sumatriptan injection) include:

pain and redness at injection site, tingling or numbness, dizziness, warm/hot sensation, burning sensation, feeling of heaviness, pressure sensation, flushing, and feeling of tightness.

ZEMBRACE SYMTOUCH may cause triptan‑related side effects, such as:

  • Fluttering, fast, or pounding
    heartbeat
  • Nausea
  • Chest discomfort
  • Dizziness
  • Fatigue
  • Tingling or numbness
  • Shortness of breath
  • Throat irritation or tightness

However, in clinical trials, more than 90% of patients reported no triptan-related side effects.

Not an actual patient. For illustrative purposes only.

How to Use

A single‑use, pre‑filled injection device

Read the Instructions for Use before you start to use ZEMBRACE SYMTOUCH. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment. You and your healthcare provider should talk about ZEMBRACE SYMTOUCH when you start taking it and at regular checkups.

Zembrace SymTouch 3 mg auto-injector: red cap, yellow needle guard, medicine viewing window, red plunger rod.

Not actual size.

Step-by-step how to use Zembrace Symtouch

Illustration of Zembrace SymTouch auto-injector being inspected with alcohol swab and sharps container nearby

Step 1

Inspect and gather supplies

  • Remove ZEMBRACE SYMTOUCH auto-injector from the carton. Check the expiration date on the device. Inspect the medicine through the viewing window to ensure the solution is clear. Its coloring may range from colorless to pale yellow. Do not inject the medicine if the solution looks discolored or cloudy or contains lumps, flakes, or particles.
  • In addition to the auto-injector, gather an alcohol swab, sterile cotton ball or gauze, and an FDA-cleared sharps disposal container.
Illustration of injection site being cleaned with alcohol swab and red cap removed from Zembrace SymTouch

Step 2

Choose and prepare injection site

  • The recommended injection sites are the sides of the thighs and the arms. Do not inject where your skin is scarred, bruised, tender, or red, or near any open wound.
  • Clean the injection site with an alcohol swab. Don’t touch the area after cleaning.
  • Hold the body of the auto-injector in one hand and pull the red cap straight off. Do NOT touch the yellow needle guard.
Illustration of Zembrace SymTouch pressed against injection site with Click 1, Click 2 and 5 second hold

Step 3

Inject the medicine

  • Place the auto-injector straight onto your injection site at 90 degrees with the yellow needle guard facing down, gently pressed against your skin.
  • Press and hold the auto-injector down against your skin. You will hear the first “Click 1” as the injection starts. Continue to hold the device down until you hear the second “Click 2.”
  • After “Click 2,” continue to hold down and slowly count to 5 before you remove the auto-injector.
  • Once done, remove the auto-injector by lifting it straight away from your skin. The Yellow Needle Guard will drop down and lock over the needle.
Illustration of Zembrace SymTouch viewing window checked and device disposed of in sharps container

Step 4

Confirm injection and dispose

  • Confirm that the red plunger rod has filled the medicine viewing window. If it hasn’t, call your healthcare provider. Do NOT try to reuse the auto-injector.
  • Put your used auto-injector, caps, needles, and sharps in an FDA-cleared sharps disposal container only.
  • Treat the injection site with a cotton ball, gauze pad, or bandage as needed. Do not rub the injection site.

Learn about Tosymra®,
a nasal option

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See how you may save on your medication

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INDICATION

What are ZEMBRACE® SymTouch® (sumatriptan succinate) injection and TOSYMRA® (sumatriptan) nasal spray?

ZEMBRACE SymTouch and TOSYMRA are prescription medicines used to treat acute migraine headaches with or without aura in adults who have been diagnosed with migraine. ZEMBRACE SymTouch and TOSYMRA are not used to prevent or decrease the number of migraine headaches you have or for the treatment of hemiplegic or basilar migraines. ZEMBRACE SymTouch and TOSYMRA are not indicated as treatments for cluster headache or for use in children under 18 years of age.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ZEMBRACE SymTouch and TOSYMRA?

ZEMBRACE SymTouch and TOSYMRA can cause serious side effects, including heart attack and other heart problems, which may lead to death. Stop use and get emergency help if you have any signs of a heart attack:

  • discomfort in the center of your chest that lasts for more than a few minutes or goes away and comes back
  • severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded

ZEMBRACE SymTouch and TOSYMRA are not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam shows no problem.

Do not use ZEMBRACE SymTouch or TOSYMRA if you have:

  • heart problems or a history of heart problems
  • narrowing of blood vessels to your legs, arms, stomach, or kidney (peripheral vascular disease)
  • uncontrolled high blood pressure
  • hemiplegic or basilar migraines. If you are not sure if you have these, ask your healthcare provider
  • had a stroke, transient ischemic attacks (TIAs), or problems with blood circulation
  • severe liver problems
  • an allergy to sumatriptan or any of the ingredients of ZEMBRACE SymTouch or TOSYMRA
  • taken any of the following medicines in the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, ergotamines, or dihydroergotamine. Ask your healthcare provider for a list of these medicines if you are not sure
  • are taking certain antidepressants, known as monoamine oxidase (MAO)-A inhibitors or it has been 2 weeks or less since you stopped taking a MAO-A inhibitor. Ask your healthcare provider for a list of these medicines if you are not sure

Before taking ZEMBRACE SymTouch or TOSYMRA, tell your healthcare provider about all your medical conditions, including if you:

  • have high blood pressure
  • have high cholesterol
  • have diabetes
  • smoke
  • are overweight
  • have heart problems or a family history of heart problems or stroke
  • have kidney problems
  • have liver problems
  • have had epilepsy or seizures
  • are not using effective birth control
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and supplements. Especially tell your healthcare provider if you take antidepressant medicines called: selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), or monoamine oxidase inhibitors (MAOIs).

ZEMBRACE SymTouch and TOSYMRA can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert.

ZEMBRACE SymTouch and TOSYMRA may cause serious side effects including:

  • Raynaud's syndrome: changes in color or sensation in your fingers and toes
  • stomach and intestinal problems: symptoms include sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, and fever
  • problems with blood circulation to your legs and feet: symptoms include cramping and pain in your legs or hips; a feeling of heaviness or tightness in your leg muscles; burning or aching pain in your feet or toes while resting; numbness, tingling, or weakness in your legs; cold feeling or color changes in one or both legs or feet
  • hives (itchy bumps): swelling of your tongue, mouth, or throat
  • medication overuse headaches from using migraine medicine for 10 or more days each month. If your headaches get worse, call your healthcare provider
  • serotonin syndrome: a rare but serious problem that can happen in people using ZEMBRACE SymTouch or TOSYMRA, especially when used with antidepressant medicines called SSRIs or SNRIs. Call your healthcare provider right away if you have mental changes such as seeing things that are not there (hallucinations), agitation, or coma; fast heartbeat; changes in blood pressure; high body temperature; tight muscles; or trouble walking
  • increased blood pressure: significant increases have been reported, including in people with no history of high blood pressure
  • seizures have happened in people who have never had seizures before

The most common side effects of ZEMBRACE SymTouch and TOSYMRA include pain and redness at injection site (ZEMBRACE SymTouch only), tingling or numbness, dizziness, warm/hot sensation, burning sensation, feeling of heaviness, pressure sensation, flushing, feeling of tightness, application site (nasal) reactions (TOSYMRA only), abnormal taste and throat irritation (TOSYMRA only).

Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of ZEMBRACE SymTouch and TOSYMRA. For more information, ask your healthcare provider.

This is the most important information to know about ZEMBRACE SymTouch and TOSYMRA, but it is not comprehensive. For more information, talk to your healthcare provider and read the Patient Information and Instructions for Use. You can also visit https://www.tonixpharma.com or call Tonix Medicines, Inc. at 1‑888‑869‑7633.

Please see additional safety information in the full Prescribing Information for ZEMBRACE SymTouch and TOSYMRA.

Call your healthcare provider for medical advice about side effects. You may report side effects to Tonix Medicines, Inc. at 1‑888‑869‑7633 or to the FDA at 1‑800‑FDA‑1088 or www.FDA.gov/medwatch.

MLT‑DTC‑260006 05/26

MLT‑DTC‑260003 05/26